Avanafil (stendra) Powder
Raw Avanafil Powder Details
Molecular Formula: C23H26ClN7O3
Molecular Weight: 483.95
Melt Point: 150-152°C
Storage Temp: RT
Color: White powder
Use: treat erectile dysfunction
What is Avanafil and How Avanafil Raw Powder Works?
Avanafil, which the F.D.A. approved April 27, 2012, as a remedy for male sexual Dysfunction. Like Sildenafil, Tadalafil, and Vardenafil, it is a phosphodiesterase type 5 inhibitor (PDE5 inhibitor). Developed by Vivus Inc., the product name Stendra.
Raw Avanafil powder is in a class of medications called phosphodiesterase (PDE) inhibitors.It is used to treat erectile dysfunction (ED: impotence; inability to get or keep an erection in men). This male enhancement product got its name from its main active ingredient which helps the circulation of blood in the body in a normal way. There are other ingredients that makes Raw Avanafil powder effective but don’t have that much impact and effects that its main ingredient has to offer.
It works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Raw Avanafil powder does not cure erectile dysfunction or increase sexual desire. Raw Avanafil powder does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).
Raw Avanafil powder is an oral drug that is used for treating impotence (the inability to attain or maintain a penile erection), also known as erectile dysfunction (ED). It is in a class of drugs called phosphodiesterase inhibitors that also includes tadalafil (Cialis powder), sildenafil (Viagra) and vardenafil (Levitra). Erection of the penis is caused by the filling of the penis with blood. Filling occurs because the blood vessels that bring blood to the penis increase in size and deliver more blood to the penis, and, at the same time, the blood vessels that take blood away from the penis decrease in size and remove less blood from the penis. Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the penis. The nitric oxide causes an enzyme, guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is cGMP that is primarily responsible for increasing and decreasing the size of blood vessels carrying blood to and from the penis, respectively, and causing an erection. When the cGMP is destroyed by another enzyme, phosphodiesterase-5, the blood vessels return to their normal size, blood leaves the penis, and the erection ends. Raw Avanafil powder prevents phosphodiesterase-5 from destroying cGMP so that cGMP stays around longer. The persistence of cGMP leads to a more prolonged engorgement of the penis with blood.
Clinical Research Of Avanafil Powder
A multicenter phase II study results indicate that avanafil NuMei company (I) in patients with erectile dysfunction (ED) is effective. 284 patients were taking (I) 50, 100, 200 or 300 mg or placebo, trying to have sex before 30 minutes, sharing of 12 weeks. Compared with the placebo group, taking (I) 50, 100, 200 and 300 mg treatment makes the erection, the ratio of the inserted into the vagina were 76%, 79%, 80% and 84% respectively (p < 0. 001); In addition, 54 percent, 59 percent, 62 percent and 64 percent of men who had an erection long enough to have successful sex had one.
Let’s look at the results of one 12-week Phase III trial in particular. A total of 646 men were randomly assigned to take either 50, 100, or 200 mg of Avanafil powder 30 minutes before initiating sexual activity. There were no restrictions on food or alcohol use. Of the 300 sexual attempts made during the study, 64% to 71% were successful among men who took Raw Avanafil powder compared with 27% among men who took placebo. Other good news: 59% to 83% of the 80 attempts at sexual intercourse made more than 6 hours after taking Raw Avanafil powder were successful compared with only 25% successful attempts in men who took placebo. In some men, Avanafil powder worked in as little as 15 minutes. (Goldstein 2012)
Avanafil Powder vs Sildenafil Powder
There a few different perspectives on this topic. Medications such as Viagra (sildenafil), Cialis (tadalafil), Stendra (avanafil) and Levitra (vardenafil) are commonly used for the treatment of erectile dysfunction in men. In some ways, these medications are like Pepsi and Coke, very similar but each has its own fans.
Major differences between these medications are attributable to the speed and duration of their action. Individual patients also respond differently to medications such as Sildenafil and Avanafil with one patient responding better to one medication than to the other. This is likely due to genetic differences among individual patients.
Avanafil Powder works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. The advantage of avanafil is that it has very fast onset of action compared with other sex enhancing hormones. It is absorbed quickly, reaching a maximum concentration in about 30–45 minutes.